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Altogether, our knowledge present proof with the potential of mixing CX-5461 and PARPi for enhancing the remedy of HR-deficient HGSOC. We display that CX-5461 improves the synthetic lethal interaction of PARPi with HRD and clearly show that CX-5461 has a special mechanism of motion to PARPi. Importantly, we characterised BRCA-mutated and MYC target